MultiPep CF

The MultiPep CF is a fully automated peptide synthesizer with a unique column module that allows the synthesis of long and difficult sequences. Optional UV monitoring in real-time enables the optimization of reaction parameters like deprotection and coupling times during the synthesis. The continuous monitoring can be used to automatically adapt the number of washing steps as well. This leads to a significant reduction of solvent consumption. The MultiPep CFis a very good peptide synthesizer with a real-time UV monitoring. The UV monitoring is done in the continuous flow.

The MultiPep CF can be upgraded with a 48 or 72 column module for the parallel synthesis of peptides at 10-500µmol scales. The instrument is based on a pipetting robot with a single needle. A multi-channel manifold is used for rapid solvent delivery and washing via a robust pump connected to a ceramic 6-port valve.
The column module allows the parallel synthesis in disposable filter columns at 10-100, 50-300 or 100-500µmol scales respectively. Vortexing and heating options ensure reliable agitation of reagents and resin by optimizing reaction conditions at larger scales.

The instrument covers the requirements of core facilities, research laboratories and custom synthesis houses. Up to 13 solvent and reagent bottles offer the flexibility to run complex chemistry protocols.

Available modules:

    • 1-Column Module: single column, 0.05-2mmol scales; optional real-time UV monitoring
    • Column Module: multiple synthesis upgrade, up to 72 peptides; 10-500µmol scales

The continuous flow module which allows synthesis of long and difficult sequences. Optional UV monitoring in real-time enables the optimization of reaction parameters like deprotection and coupling times during the synthesis.

 

With this module the MultiPep CF performs fully automated solid phase peptide synthesis for either 48 or 72 columns in parallel. It features a wide range of peptide numbers and synthesis scales operating fully optimized Fmoc protocols.
more